Do you feel drowsy when you’re at work? If not, I don’t think it’s the meds, hunni, it’s struggling with not being in the work environment.
As for the clothes - stop feeling crap in them - go online and buy yourself a few things that actually fit you and you can feel good in. I know how hard it is to buy larger sizes, but just think how good it’ll feel when you lose that bit of extra weight (that most of us have put on during the last year) and can get comfortably back into your old clothes!