My husband has been fairly recently changed to them after years of high doses of fluoxetine. He just pretty much slept the first weekend he took them, and then after his first increase.. He still gets tired easily, but as he says if that's the only side effect he's going to get then so be it! He's currently the most stable he's been in a while. Although if he misses a dose then he get's withdrawal quite fast which gives him similar to a migraine...