I know what you mean but this could still work without any trouble. I had previously had problems with meds and started to feel like nothing would work for me and I was in a really bad place when I started Duloxetine but the difference it made was almost instant. Within 2-3 days I was feeling so much better and able to see things clearly, which did cause a big guilt trip but even so I knew I deserved it and I also knew I was lucky to still be here to have another chance.Try and be positive about the change because you have said the old meds were holding you back over losing weight. This could be the change that balances everything out