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I haven't had experience of them together, only separately. I must admit I did not get along too well with Sertraline. I didn't have any side effects, but I felt disconnected from my emotions and therefore decisions became very difficult. Its difficult to know if this was due to the medication or symptoms of depression.
With regards to Quetiapine, I only take 50mg a night and its been an absolute life-saver for me.
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