I've been on Duloxetine for almost 3 yrs now and it's made a huge difference to my life. It literally took just a couple of days before I started to notice a change and was the first time I was about to think clearly for years. Never experienced any of the side effects others have experienced although I did have a spell where I stopped taking them and on starting again everything I ate went straight through me. This is also something I experience when stressed and after 3 weeks in died down again. I am taking 120mg along with Mirtazapine 30mg(to help with my insomnia) and both seem to do the job of keeping me relatively stable.