I was on venlafaxine 300mg for past 2 years. I tolerated it ok although on the occasional times i flipped and stopped all my meds it was a killer with side effects. Dont do it!!!! Dr has recently decided to try something different as hasn't given me the kick that they felt I should have got. Weened down off it slowly by 75mg each time and they then introduced Citalopram, first 10mg and now 20mg. not sure how I'm feeling about it tbh but am willing to try anything, although tbh they do feel that working with psychology is going to make the biggest impact on my mental health.