I take my Venlafaxine in the morning with my breakfast.
I am allowed to take the Zopiclone every third night - I have enough to last me for quite a few weeks on this schedule. My old GP had me on it for 2 years every third night and it was no problem. It really knocks me out and I get a good uninterrupted 7 - 8 hours sleep. This makes such a difference to my mood and state of mind. The GP is fully aware of this.