I take duloxetine, 60mg at the moment (was on 90 but reduced to 60 and introduced 30 mirtazapine) and did have some weight gain but that was more likely to be the office job I started at a similar time after a really active job. 30mg is quite a low dose as 120 is the maximum. It does make you thirsty and pee a lot which is no bad thing as long as you're drinking the right stuff! It's a good anti-depressant but it stopped working so well for me after a number of years hence the introduction of mirtazapine. I don't really remember any unbearable side effects aside the usual dry mouth but it didnt increase my appetite.