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Thread: Duloxetine combination for treatment resistant dep

  1. #1

    Duloxetine combination for treatment resistant dep

    Hi I'm new here. Been on anti depressants for depression and anxiety for over 20 years. I've managed finally to reduce my Duloxetine sufficiently to try augmentation with another drug. My mental health team asked me today, had I looked at different meds to augment with Duloxetine. I'm very interested to here what combinations others have tried. I've been on Duloxetine 120 mg and quetiepine 100, some affect but still very low and anxious. I'm down to 75 mg Duloxetine now and 15 mg quetiepine, so am in a very good position for my psychiatrist to try another strategy.

    Lithium has been mentioned. As its a mood balancer it worries me that I won't be able to feel happy. ( not that I ever do anyway).

    Mirtazipine has been mentioned.

    Aripiprazole, but can't take it because of impulse control side affects, and I'm a recovering alcoholic, 18 months sober.

    Any info would be gratefully appreciated

  2. #2
    I’m on Duloxetine 120 and Mirtazapine 45. Duloxetine is the best drug for me so far regarding my mood and the Mirtz helps me to sleep. It’s not perfect but it all keeps me relatively stable.

  3. #3
    Thank you xxx

  4. #4
    Princess Sparkles Paula's Avatar
    Join Date
    Sep 2012
    Jane Austen country
    Hi and welcome. Iíve not taken duloxetine but have taken lithium and mirtazapine.. Mirtazapine is a very effective AD for a lot of people. Iíve had it in combination with various ADs and with lithium. It makes you very drowsy so is normally taken at night - so if you struggle with sleep itís a good one to try. The biggest side effect it has is that it does cause weight gain - and most people have this side effect. Donít ever take the soluble tablets - they taste foul

    Lithium is a mood stabiliser. It doesnít work until thereís a sufficient level of lithium in your bloodstream so youíll be getting frequent blood tests to begin with to increase the dose til itís at the right level. Of all the meds Iím on, lithium is the one Iíd never let them stop as itís the key to my health. However, it does come with risks of a lot of side effects. It can affect your thyroid, your liver, kidneys etc. Lithium toxicity is a risk too so youíd need bloods every 3 months to check all these factors. Lithium is also contraindicated with all sorts of other medications inc anti inflammatories - it doesnít play nicely.

    Given all this, Iíve been on lithium for over a decade which, I think, speaks volumes to how effective it is for me - Iíd rather deal with all the side effects than stop taking it. But when my psychiatrist first talked to me about it, she told me to go away and research the drug before we made a decision as itís not an easy drug to deal with.

    When Iím well, I do feel the full range of emotions but they are easier for me to deal with itms. Hope this helps
    ĎWhen all else fails, use glitter insteadí

    Makaluluís Treasures can be found at

  5. #5
    Of course just cos it works for me doesn’t mean it will have the same effect on everyone.

  6. #6
    Thank you so much xxx

  7. #7
    Boss Lady ;) Suzi's Avatar
    Join Date
    Feb 2012
    Surrey. UK
    Hi and welcome. I think it's great that you've been given the time to investigate and to look around. It's good that you've got a sensible care team.
    Please always remember that I am always right. I have a framed certificate to prove it.

    When in doubt, stop and think... WWSS? (What Would Suzi Say?)
    For more info please see
    THIS thread

  8. #8
    Today they told me 'I'm not the doctor'!!

    Any tried buspirone and Duloxetine for depression and anxiety

    Hank you

  9. #9

    Duloxetine combination therepy

    Can anyone please advise what they have tried combining with Duloxetine . I've been looking at Wellbutrin , but need info to take with me to psychiatrist. I really don't want to take something that's going to make me put weight on. Or buspirone ?
    I have depression and anxiety and it's time for a med change.

  10. #10
    It’s probably best to discuss the best option for you with your doctor.

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